This renovation of a 38,000 sq. ft. ground floor and 11,000 sq. ft. mezzanine of an existing facility consolidated all MIS research and manufacturing operations. Spaces included administrative and engineering office suites, R&D laboratories, extrusion shop, a 10,000 sq. ft., class 100,000, clean room, employee lunchroom, and storage and shipping areas. Work was done in close collaboration with in-house regulatory personnel to minimize difficulties with manufacturing validation.